=========== HEADER =========== Readme.txt for Association of heightened host and tumor immunity with prolonged duration of response to checkpoint inhibition across solid tumors Item Handle: https://hdl.handle.net/11243/52 Documentation written on 2025-02-11 By Santosh Philips =========== SUGGESTED DATA CITATION =========== Please cite this data in the references for any publication which uses it. Philips, S., Lu, P., Fausel, C., Wagner, t., Jiang, G., Shen, F., Cantor, E., Tran, M., Roland, L. M. & Bryan P. Schneider (2025). Association of heightened host and tumor immunity with prolonged duration of response to checkpoint inhibition across solid tumors (Version 1) [data set]. IU Indianapolis. https://doi.org/10.7912/6JTE-HS52 =========== PRIMARY STUDY INFORMATION =========== ACKNOWLEDGEMENTS Project title: Association of heightened host and tumor immunity with prolonged duration of response to checkpoint inhibition across solid tumors Investigator Name: Bryan P. Schneider Investigator Institution: Indiana University Investigator Address: 535 Barnhill Drive, RT 473, Indianapolis, Indiana, 46202, USA Investigator Email: bpschnei@iu.edu Investigator Role (related to this dataset): Principal Investigator Other contributors to the project: Santosh Philips Pei Lu Chris Fausel Thomas Wagner Guanglong Jiang Fei Shen Erica Cantor Mya Tran Lauren M. Roland DATE(S) of DATA COLLECTION Start date: 2013-11-19 End date: 2020-09-25 GEOGRAPHIC LOCATION(S) of DATA COLLECTION Indianapolis, Indiana, 46202, USA DIRECTORY/FILE NAMING CONVENTIONS Sample IDs have the format that indicates both the therapy duration and the sequential number assigned to each sample within its respective therapy duration group. Each sample is assigned an ID following the format: therapy duration - sequential number [E.g., 3M-01 is the first sample within the 3 month duration of therapy group.] For the peptides data, each sample has its own file, named using the same format as the sample ID with the addition of a suffix _Peptide.txt. [E.g., 12M_12_Peptide.txt contains the pepdite data for the twelfth sample within the 12 month duration of therapy group] FILE INFORMATION manuscript_files.zip vcfs germline_variants.vcf tumor_epha8_variants.vcf tmb tmb_values.txt rna_tpm rna_expression_tpm.txt hla germline_hla_alleles.txt peptides 12M_01_Peptide.txt 12M_02_Peptide.txt 12M_03_Peptide.txt 12M_04_Peptide.txt 12M_05_Peptide.txt 12M_06_Peptide.txt 12M_07_Peptide.txt 12M_08_Peptide.txt 12M_09_Peptide.txt 12M_10_Peptide.txt 12M_11_Peptide.txt 12M_12_Peptide.txt 12M_13_Peptide.txt 12M_14_Peptide.txt 12M_15_Peptide.txt 12M_16_Peptide.txt 12M_17_Peptide.txt 12M_18_Peptide.txt 12M_19_Peptide.txt 12M_20_Peptide.txt 12M_21_Peptide.txt 12M_22_Peptide.txt 12M_23_Peptide.txt 12M_24_Peptide.txt 12M_25_Peptide.txt 12M_26_Peptide.txt 12M_27_Peptide.txt 12M_28_Peptide.txt 12M_29_Peptide.txt 12M_30_Peptide.txt 12M_31_Peptide.txt 12M_32_Peptide.txt 12M_33_Peptide.txt 12M_34_Peptide.txt 12M_35_Peptide.txt 3M_01_Peptide.txt 3M_02_Peptide.txt 3M_03_Peptide.txt 3M_04_Peptide.txt 3M_05_Peptide.txt 3M_07_Peptide.txt 3M_08_Peptide.txt 3M_09_Peptide.txt 3M_10_Peptide.txt 3M_11_Peptide.txt 3M_12_Peptide.txt 3M_13_Peptide.txt 3M_14_Peptide.txt 3M_15_Peptide.txt 3M_16_Peptide.txt 3M_17_Peptide.txt 3M_18_Peptide.txt 3M_19_Peptide.txt 3M_20_Peptide.txt 3M_21_Peptide.txt 3M_22_Peptide.txt 3M_23_Peptide.txt 3M_24_Peptide.txt 3M_25_Peptide.txt 3M_26_Peptide.txt 3M_27_Peptide.txt 3M_28_Peptide.txt 3M_29_Peptide.txt 3M_30_Peptide.txt 3M_31_Peptide.txt 3M_32_Peptide.txt 3M_33_Peptide.txt 3M_34_Peptide.txt 3M_35_Peptide.txt 3M_36_Peptide.txt 3M_37_Peptide.txt 3M_38_Peptide.txt 3M_39_Peptide.txt 3M_40_Peptide.txt 3M_41_Peptide.txt 3M_42_Peptide.txt 3M_43_Peptide.txt 3M_44_Peptide.txt 3M_45_Peptide.txt 3M_46_Peptide.txt 3M_47_Peptide.txt 3M_48_Peptide.txt 3M_49_Peptide.txt 3M_50_Peptide.txt 3M_51_Peptide.txt 3M_52_Peptide.txt 3M_53_Peptide.txt ACCESS & SHARING 1. Licenses/restrictions placed on the data (who is allowed to access and use these data?): These data are made available via request and under a Data Sharing Agreement with Indiana University. The data requeest can be initiated at https://hdl.handle.net/11243/52 by completing the request access form. Once the form is submitted, the contact person (Santosh Philips, sphilips@iu.edu) will review the request and respond. If approved, the requester's institution will work with Indiana University to establish a Data Sharing Agreement. The data will be securely transferred to the requester only after the data agreement is executed (signed by both institutions). 2. Links to thesis, dissertation, reports, or publications that cite or use the data (include DOI): To be added upon publication =========== CREDITS =========== Template provided by Indiana University UITS Research Storage, Indiana University Bloomington Libraries, IUPUI University Library